A GLP-1 Has Changed Your Life—Are You Stuck Taking It Forever?
Nearly 15% of Americans have tried a GLP-1—and for good reason. The medications show incredible promise in helping people lose a substantial amount of weight. But even those with positive experiences may find themselves wondering: Is it ever possible to stop the injections?
Studies Reveal Weight Regain After Stopping GLP-1 Drugs
Multiple studies demonstrate that when patients discontinue GLP-1 drugs, they often regain up to two-thirds of the weight lost while on treatment. With tirzepatide (known by brand names like Zepbound or Mounjaro), a trial found approximately 60% of lost weight was regained within a year after GLP-1 therapy ended.
"We don't have a good off-ramp right now," said Dr. Joshua Neal, an obesity medicine physician at the Medical University of South Carolina.
Options for Quitting GLP-1 Medication
While going back to their original weight management plan may be necessary for some, there are alternatives:
- Gradual Reduction: Working closely with a healthcare provider, individuals can slowly taper off the medication over time.
- Switching Medications: Exploring other weight loss medications or combinations might offer sustained results.
- Lifestyle Interventions: Focusing on diet, exercise, and behavior change can help maintain weight loss achieved while on GLP-1 therapy.